Reference
Ipamorelin vs CJC-1295
Two peptides that are often sold in the same vial, built on two different hormones and aimed at two different receptors.
Ipamorelin and CJC-1295 are paired so often that they can seem like one product. They are two separate molecules with separate histories, made by different companies. This page compares what each is built on; it makes no claim about what either does.
| Ipamorelin | CJC-1295 | |
|---|---|---|
| Length | 5 amino acids | 29 amino acids (plus DAC in one form) |
| Modelled on | Ghrelin, the "hunger hormone" | GHRH, growth-hormone-releasing hormone |
| Receptor | Growth hormone secretagogue (ghrelin) receptor | GHRH receptor |
| Developed by | Novo Nordisk, 1998 | ConjuChem, early 2000s |
| Furthest trial | Phase 2 (117 patients after bowel surgery) | Phase 2 (192 participants, stopped 2006) |
| Approved? | No | No |
Two hormones, two receptors
The pituitary gland responds to more than one signal. One is GHRH, from the hypothalamus. Another is ghrelin, the hormone the stomach releases when it is empty, which acts at a separate receptor. CJC-1295 is built on the first; Ipamorelin mimics the second. That is the whole reason they are discussed as a pair: they are aimed at different receptors rather than competing for the same one.
Ipamorelin
A five-amino-acid peptide made by Novo Nordisk, the company behind Ozempic, and described in 1998 as “the first selective growth hormone secretagogue”. “Selective” was the point: earlier compounds acting at the ghrelin receptor also raised cortisol and prolactin, and ipamorelin was designed not to. Its one mid-stage trial, in 2008–09 in patients recovering from bowel surgery, did not beat placebo, and development stopped.
CJC-1295
A modified 29-amino-acid fragment of GHRH. It is sold with or without DAC, a chemical hook that lets it bind a blood protein; the difference is large enough to have its own page. Its developer stopped the programme in 2006.
In one vial
The combined vial on the CJC-1295 page pairs CJC-1295 without DAC with ipamorelin. Like any blend, it is two molecules freeze-dried together, not a new one: what a peptide blend is.
Buy in New Zealand
Prices, sizes and stock: Ipamorelin in New Zealand · CJC-1295 in New Zealand.
